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Zosuquidar trihydrochloride
CAS No. 167465-36-3
Zosuquidar trihydrochloride ( LY-335979 trihydrochloride )
产品货号. M12557 CAS No. 167465-36-3
A potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥324 | 有现货 |
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| 5MG | ￥518 | 有现货 |
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| 10MG | ￥729 | 有现货 |
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| 50MG | ￥3062 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Zosuquidar trihydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM.
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产品描述A potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM; fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM; enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.Blood Cancer Phase 3 Discontinued
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同义词LY-335979 trihydrochloride
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通路Membrane Transporter/Ion Channel
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靶点P-glycoprotein
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受体P-gp(P-glycoprotein)
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number167465-36-3
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分子量636.99
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分子式C32H34Cl3F2N3O2
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESFC1([C@H]2[C@@H]1C3=C([C@@H](C4=CC=CC=C42)N5CCN(CC5)C[C@H](COC6=C7C=CC=NC7=CC=C6)O)C=CC=C3)F.Cl.Cl.Cl
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化学全称1-Piperazineethanol, 4-[(1a.alpha.,6.alpha.,10b.alpha.)-1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-.alpha.-[(5-quinolinyloxy)methyl]-, hydrochloride (1:3), (.alpha.R)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Slate DL, et al. Anticancer Res. 1995 May-Jun;15(3):811-4.
2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.
3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.
2. Dantzig AH, et al. Cancer Res. 1996 Sep 15;56(18):4171-9.
3. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62.
产品手册
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